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Title: ULTRATHIN MEMBRANES FOR ESTABLISHMENT OF PHYSIOLOGICALLY RELEVANT CELL BARRIERS. FOCUS ON BLOOD-BRAIN BARRIER
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ULTRATHIN MEMBRANES FOR ESTABLISHMENT OF PHYSIOLOGICALLY RELEVANT CELL BARRIERS. FOCUS ON BLOOD-BRAIN BARRIER
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1314-2704
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English
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19
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6.1
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The thickness of the blood-brain barrier (BBB) basement membrane (BM) in vivo is in the range of 20 - 200 nm. Most widely used commercially available microporous polycarbonate (PC), polyethylene terephthalate (PET) or polytetrafluoroethylene (PTFE) membranes are 10 to 50 ?m thick. This is a substantial obstacle for communication of cells growing on both sides of membrane, like astrocytes, pericytes and endothelial cells within in vitro BBB model.
For the last several years the active development of ultrathin microporous membranes is in progress. As an example, are ultrathin ceramic or polymeric nanomembranes 100 - 500 nm thick. Geometrical parameters of such artificial nanomembranes are close to the characteristics of in vivo basement membranes. However, to the date commercially available products integrated into standard cell culture vessels or microfluidic systems are almost absent. This review focuses on description of existing developments in the field of ultrathin membranes suitable for establishment of cell barriers. |
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conference
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19th International Multidisciplinary Scientific GeoConference SGEM 2019
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19th International Multidisciplinary Scientific GeoConference SGEM 2019, 30 June - 6 July, 2019
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Proceedings Paper
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STEF92 Technology
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International Multidisciplinary Scientific GeoConference-SGEM
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Bulgarian Acad Sci; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Russian Acad Sci; Serbian Acad Sci & Arts; Slovak Acad Sci; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; World Acad Sci; European Acad Sci, Arts & Letters; Ac
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475-482
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30 June - 6 July, 2019
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website
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cdrom
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6412
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blood-brain barrier; BBB; basement membrane; microporous membrane; ultrathin membrane
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