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Title: ANTIPROLIFERATIVE EFFECT OF POLYVINYLPYRROLIDONE-IODINE COMPLEX ON RHABDOMYOSARCOMA CELLS BY INDUCING CELL CYCLE ARREST
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ANTIPROLIFERATIVE EFFECT OF POLYVINYLPYRROLIDONE-IODINE COMPLEX ON RHABDOMYOSARCOMA CELLS BY INDUCING CELL CYCLE ARREST
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1314-2704
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English
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20
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6.1
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PVP-I (povidone-iodine) or Betadine, molecular iodine combined with poly-(1-vinyl-2-pyrrolidone), has been reported as antimicrobial agent. It is also as a promising chemopreventive agent against cancer. In this study the antiproliferative effect of PVP-I on rhabdomyosarcoma (RD) and other cancer cell lines (AGS, HeLa, HepG2, and MiaPaCa2) was examined. Cancer cells were treated with PVP-I and assessed for cell proliferation, metabolic activity, colony forming assay, apoptosis, and the fluorometric assay of the cell cycle. Our results showed that PVP-I has an antiproliferative effect and inhibits colony formation of RD cells in a dose-dependent manner. PVP-I appears to be mediated by apoptosis induction in human RD cell lines through cell cycle arrest at the G0/G1 phase. This study is the first report demonstrating the PVP-I mechanism against RD cells. Our studies may bring promising prospectus of using PVP-I in clinical practice.
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conference
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20th International Multidisciplinary Scientific GeoConference SGEM 2020
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20th International Multidisciplinary Scientific GeoConference SGEM 2020, 18 - 24 August, 2020
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Proceedings Paper
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STEF92 Technology
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International Multidisciplinary Scientific GeoConference-SGEM
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SWS Scholarly Society; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Russian Acad Sci; Serbian Acad Sci & Arts; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; European Acad Sci, Arts & Letters; Acad Fine Arts Zagreb Croatia; C
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165-174
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18 - 24 August, 2020
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website
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cdrom
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7530
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PVP-iodine; Rhabdomyosarcoma (RD); 6-iodolacton (6-IL); Cell apoptosis; Cell cycle.
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