Peer-reviewed articles 17,970 +



Title: SYNTHESIS AND CHARACTERIZATION OF AMINO ACID-BASED, ECO-FRIENDLY MATERIALS

SYNTHESIS AND CHARACTERIZATION OF AMINO ACID-BASED, ECO-FRIENDLY MATERIALS
Sophiko Kvinikadze; Davit Tsverava; Alexandre Vanishvili; Ramaz Katsarava; Nikoloz Chikhradze
10.5593/sgem2023/6.1
1314-2704
English
23
6.1
•    Prof. DSc. Oleksandr Trofymchuk, UKRAINE 
•    Prof. Dr. hab. oec. Baiba Rivza, LATVIA
Environmental pollution from polymer waste is one of the severe ecological problems. As of today, each day, approximately eight million pieces of plastic waste reach the ocean, where they are transformed into microplastics (small particles). Organisms in the sea are eating microplastics. The harmful effects of garbage ultimately affect humans.
Due to the magnitude of the problem, the demand for biodegradable, eco-friendly materials, which will decompose after the operational period and will not pollute the environment, has increased in recent years.
The latter contribute significantly to the sustainable development of the economy, as they are characterized by a wide range of uses and zero or minimal environmental impact [1-2].
The presented research concerns the synthesis of rigid structure monomers and biodegradable polymers based on them. Monomers tosyl diamino-diesters (TDADE) were synthesized by thermal condensation of amino acids and cyclic diols in a refluxed organic solvent. For the synthesis of polymers, we used the interfacial polycondensation method - we synthesized pseudoproteins of poly(ester urea) class (PP-PEU) by polycondensation of TDADE monomers with triphosgene.
The paper presents the synthesis of six new monomers - TDADE and the preparation of some rigid structured poly(ester urea) based on them. Polymers of this type are actively used mainly in the medical field, however, due to their mechanical characteristics, the application area is expected to be some engineering fields as well.
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[6] Yousefzade O., Katsarava R, Puiggali J., (2020) Biomimetic Hybrid Systems for Tissue Engineering. Biomimetics 5 49
[7] Zavradashvili N., Puiggali J., Katsarava R., (2020) Artificial polymers made of ?- amino acids – Poly(Amino Acid)s, Pseudo-Poly(Amino Acid)s, Poly(depsipeptide)s, and Pseudo-Proteins, Current Pharm.Design., 26 (5), 566-593
[8] Kobauri S., Kantaria T., Kupatadze N., Kutsiava N., Tugushi D., Katsarava R., (2019) Pseudo-proteins: A new family of biodegradable polymers for sophisticated biomedical applications, Nano Technology & Nano Science Journal, 1, 37-42
[9] Katsarava R., Tugushi D., Gomurashvili Z.D., (2014) Poly (ester urea) Polymers and Methods of Use. U.S. Patent No. 8,765,164
[10] Stakleff K.S., Lin F., Smith Callahan L.A., Wade M.B., Esterle A., Miller J., Becker M.L., (2013) Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity. Acta Biomater. 9, 5132-5142
[11] Policastro G.M., Lin F., Smith Callahan L.A., Esterle A., Stakleff K S., Becker M.L., (2015) OGP functionalized phenylalanine-based poly (ester urea) for enhancing osteoinductive potential of human mesenchymal stem cells. Biomacromolecules. 16, 1358-1371
[12] Policastro G., Lin F., Esterle A., Harris F., Graham M., Katsarava R., Stakleff K.S., Becker M.L., (2015) OGP Functionalized Phenylalanine-based Poly(ester urea) for Enhancing Osteoinductive Potential of human Mesenchymal Stem Cells. 249th ACS National Meeting & Exposition, March 22-26, Denver, CO, USA
[13] Gomurashvili Z., Kricheldorf H.R., Katsarava R., (2000) Amino acid based bioanalogous polymers. Synthesis and study of new regular poly(ester amides)s composed of hydrophobic ?-amino acids and dianhydrohexitoles. J.Macromol. Sci.- Pure and Appl. Chem. 37, 215-227
[14] Fenouillot F., Rousseau A., Colomines G., Saint-Loup R., Pascault J-P., (2010) Polymers from renewable 1,4:3,6-dianhydrohexitols (isosorbide, isomannide and isoidide): a review. Progress in Polymer Science, DOI: 10.1016/j.progpolymsci.2009.10.001
Research [PHDF-21-184] was supported by the Shota Rustaveli National Science Foundation of Georgia. ("Synthesis and research of high mechanical strength, polyesterurea class pseudoproteins").
conference
Proceedings of 23rd International Multidisciplinary Scientific GeoConference SGEM 2023
23rd International Multidisciplinary Scientific GeoConference SGEM 2023, 03 - 09 July, 2023
Proceedings Paper
STEF92 Technology
International Multidisciplinary Scientific GeoConference SGEM
SWS Scholarly Society; Acad Sci Czech Republ; Latvian Acad Sci; Polish Acad Sci; Serbian Acad Sci and Arts; Natl Acad Sci Ukraine; Natl Acad Sci Armenia; Sci Council Japan; European Acad Sci, Arts and Letters; Acad Fine Arts Zagreb Croatia; Croatian Acad Sci and Arts; Acad Sci Moldova; Montenegrin Acad Sci and Arts; Georgian Acad Sci; Acad Fine Arts and Design Bratislava; Turkish Acad Sci.
337-344
03 - 09 July, 2023
website
9254
Biodegradable polymers, Eco-friendly materials, Synthesis of polymers, Synthesis of monomers, Poly(ester urea)s

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