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The presented paper deals with the targeted application of pre-emergent herbicides. The field experiment was established in 2022 and 2023; two plots sized 26 ha and 30 ha were selected and the accuracy of the application was tested. There were local outbreaks of weeds on selected plots of land, which had to be eliminated before sowing the main crop - soybeans. Both plots were monitored using an unmanned aerial vehicle (UAV) - Mavic 3M with the multispectral camera. After the end of the monitoring, spectral analysi...