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Summary. Aluminum, entering the human body, has the property of accumulation, modulates immunoregulation and metabolism, especially mineral. It also exhibits the properties of a sensitizer and neurotoxicant, mutagen and carcinogen. And in the case of aerogenic exposure, the target object is additionally the upper and lower respiratory tract system. Exposed by aluminium children are especially inclined to occurrence of negative effects. The research is aimed to study the immune status of children of primary school ...

Anthropogenic factors of the production environment of oil production are characterized by more intensive influence of these factors in contrast to the external environment, which can create the prerequisites for early development of adaptation disorders, functional changes in immune and humoral regulation, especially with their genetic determinism, and the formation of an increased risk of development and weighting of cardiovascular pathology in those engaged in oil production. The aim of the work was to study th...

Introduction Violations of autonomic nervous regulation are a multifactorial pathology, while environmental features are an important risk factor for this pathology. Excessive exposure to neurotropic technogenic chemical factors, including benzene, to the biological environment of the human body induces malfunctions of adaptive-compensatory mechanisms and forms an increased risk of developing disorders of autonomic regulation associated with the immune system, which are realized against the background of polymorph...

Introduction. The Eastern region of the European part of Russia (Perms Krai) is characterized by the peculiarities of the wind regime, the presence of large highways and petrochemical enterprises. Aromatic hydrocarbons (AH) are highly prevalent in the environment and are found in emissions from vehicles and industrial plants. These substances belong to hormone-like xenobiotics, which are capable of making adjustments to the work of immune and hormonal regulation. Purpose of the work: analysis of the features and p...

Drinking water contamination with technogenic haptens forms an imbalance in the adaptive capabilities of the immune system in children. The aim of this work is to study the features of laboratory markers of the cytokine profile in children, probabilistically associated with an increased content of chloroform in the blood. Materials and methods. The study involved 283 children living in conditions of chronic low-level oral exposure to hyperchlorination products of drinking water, the control for which was a conting...

Introduction. The extreme nature of environmental meteorological factors and the asynchronous change of day and night are considered to be one of the reasons leading to a decrease in the life quality in the Extreme North. These might lead to a violation of adaptive mechanisms under certain conditions. The combination of variants of polymorphic candidate genes causes functional disorders of the cardiovascular system. The research aims at studying the genetic polymorphism in children having pathologies of the cardio...

The peculiarities of ecological conditions determine different scenarios of adaptive changes in the immune and genetic status with the subsequent formation of eco-caused pathology. Purpose of the study: analysis of the peculiarities of the immunological and genetic status of the child population in the extreme conditions of the Arctic Circle of Russia under the combined impact of anthropogenic chemical and climatogeographic factors. Materials and methods . Immunological and genetic testing of 98 children (the terr...

The authors have conducted an experiment that involved modeling of interactions between immune regulation mechanisms applying a viral load simulator in vitro. The experiment was performed on a suspension that contained immune cells extracted from peripheral blood samples (68 samples overall). There were several influencing factors such as impacts exerted by managing elements including cytokines (IL-1), hydrocortisone, and exogenous environmental factors represented by aluminum compounds (aluminum oxide) as well as...

Today, the analysis of the unique contribution to the formation of the ?genetic portrait? of regional features, including technogenic ones, which determines the occurrence of diseases and harm to health, is relevant. The use of modern critical genetic and cellular biotechnologies with the study of genetic polymorphism and thin cell subpopulations will allow us to catch the earliest violations of homeostatic indicators in geochemical technogenic provinces. The aim of the work is to assess the features of genetic in...

This study aims to assess the influence of anthropogenic chemical factors on the formation of comorbid conditions associated with pancreatic pathology under combined gene polymorphism. The urgency of the problem lies in the disruption of the ecological balance and pathological adaptation of the organism to an excessive level of ecological anthropogenic factors due to compensatory negative shifts in genetic homeostasis. The real-time polymerase chain reaction with allelic discrimination was used to study the polymo...